Radiosensitizing effects of TMZ observed in vivo only in a subset of MGMT methylated GBM xenografts

PURPOSE: Concurrent temozolomide (TMZ) and radiation therapy (RT) followed by adjuvant TMZ is standard treatment for patients with GBM, although the relative contribution of concurrent versus adjuvant TMZ is unknown. In this study, the efficacy of TMZ/RT was tested in a panel of 20 primary GBM xenog...

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Autores principales: Carlson, Brett L., Grogan, Patrick T., Mladek, Ann C., Schroeder, Mark A., Kitange, Gaspar J., Decker, Paul A., Giannini, Caterina, Wu, Wenting, Ballman, Karla A., James, C. David, Sarkaria, Jann N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773462/
https://ncbi.nlm.nih.gov/pubmed/19695438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.04.026
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