DDRE-28. EGFR INHIBITION DOWNREGULATES MGMT AND SENSITIZES GBM CELLS TO TMZ

Glioblastoma (GBM) is a highly malignant type of adult brain tumor with a poor prognosis. Temozolomide (TMZ), a DNA alkylating agent, has been widely used as an effective first-line chemotherapeutic agent for the treatment of GBM patients. The efficacy of TMZ in GBM depends on the absence of the DNA...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Guo, Gao, Gong, Ke, Sarkaria, Jann, Habib, Amyn
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Drug Discovery, Drug Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651590/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.273
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