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DRES-17. ACTIVATION OF FGF SIGNALING PATHWAY CONFERS RESISTANCE TO EGFR INHIBITION IN GBM
Amplification and mutation of the EGFR gene is a signature lesion in GBM and occurs in 40–50% of GBM patients. However, EGFR inhibition has been ineffective in the treatment of GBM. Resistance to EGFR inhibition may be primary or secondary after an initial period of susceptibility suggesting that ad...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216568/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.324 |
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