Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target thes...

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Bibliografiska uppgifter
Huvudupphovsmän: Rao, Ravi D, Mladek, Ann C, Lamont, Jeffrey D, Goble, Jennie M, Erlichman, Charles, James, C David, Sarkaria, Jann N
Materialtyp: Artigo
Språk:Inglês
Publicerad: Neoplasia Press Inc. 2005
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502028/
https://ncbi.nlm.nih.gov/pubmed/16242075
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