Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma

PURPOSE: Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies. EGFR is overexpressed in ES; using preclinical models, we examined the ES EGFR role and assessed anti-ES EGFR blockade effects, alone and with mTOR i...

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Autors principals: Xie, Xianbiao, Ghadimi, Markus PH, Young, Eric D., Belousov, Roman, Zhu, Quan-sheng, Liu, Juehui, Lopez, Gonzalo, Colombo, Chiara, Peng, Tingsheng, Reynoso, David, Hornick, Jason L, Lazar, Alexander J, Lev, Dina
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176924/
https://ncbi.nlm.nih.gov/pubmed/21821699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0660
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