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IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

Background: Therapies cotargeting insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived, clinical responses in a subset of Ewing sarcoma (ES) patients. However, the mechanisms of resistance and applicable strategies f...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Natl Cancer Inst
Main Authors: Lamhamedi-Cherradi, Salah-Eddine, Menegaz, Brian A., Ramamoorthy, Vandhana, Vishwamitra, Deeksha, Wang, Ying, Maywald, Rebecca L., Buford, Adriana S., Fokt, Izabela, Skora, Stanislaw, Wang, Jing, Naing, Aung, Lazar, Alexander J., Rohren, Eric M., Daw, Najat C., Subbiah, Vivek, Benjamin, Robert S., Ratan, Ravin, Priebe, Waldemar, Mikos, Antonios G., Amin, Hesham M., Ludwig, Joseph A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241894/
https://ncbi.nlm.nih.gov/pubmed/27576731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw182
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