IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

Background: Therapies cotargeting insulin-like growth factor receptor 1 (IGF-1R) and mammalian target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived, clinical responses in a subset of Ewing sarcoma (ES) patients. However, the mechanisms of resistance and applicable strategies f...

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Publicado no:J Natl Cancer Inst
Main Authors: Lamhamedi-Cherradi, Salah-Eddine, Menegaz, Brian A., Ramamoorthy, Vandhana, Vishwamitra, Deeksha, Wang, Ying, Maywald, Rebecca L., Buford, Adriana S., Fokt, Izabela, Skora, Stanislaw, Wang, Jing, Naing, Aung, Lazar, Alexander J., Rohren, Eric M., Daw, Najat C., Subbiah, Vivek, Benjamin, Robert S., Ratan, Ravin, Priebe, Waldemar, Mikos, Antonios G., Amin, Hesham M., Ludwig, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241894/
https://ncbi.nlm.nih.gov/pubmed/27576731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw182
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