Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous mTOR and EGFR Inhibition in GBM Cells

Elevated epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) signaling are known to contribute to the malignant properties of glioblastoma multiforme (GBM), which include uncontrolled cell proliferation and evasion of apoptosis. Small molecule inhibitors that target thes...

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Detalhes bibliográficos
Main Authors: Rao, Ravi D, Mladek, Ann C, Lamont, Jeffrey D, Goble, Jennie M, Erlichman, Charles, James, C David, Sarkaria, Jann N
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502028/
https://ncbi.nlm.nih.gov/pubmed/16242075
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