ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells

Ataxia telangiectasia mutated (ATM) kinase is critical in sensing and repairing DNA double-stranded breaks (DSBs) such as those induced by temozolomide (TMZ). ATM deficiency increases TMZ sensitivity, which suggests that ATM inhibitors may be effective TMZ sensitizing agents. In this study, the TMZ...

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מידע ביבליוגרפי
Main Authors: Nadkarni, Aditi, Shrivastav, Meena, Mladek, Ann C., Schwingler, Paul M., Grogan, Patrick T., Chen, Junjie, Sarkaria, Jann N.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535329/
https://ncbi.nlm.nih.gov/pubmed/23054561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-012-0979-0
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