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ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells
Ataxia telangiectasia mutated (ATM) kinase is critical in sensing and repairing DNA double-stranded breaks (DSBs) such as those induced by temozolomide (TMZ). ATM deficiency increases TMZ sensitivity, which suggests that ATM inhibitors may be effective TMZ sensitizing agents. In this study, the TMZ...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535329/ https://ncbi.nlm.nih.gov/pubmed/23054561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-012-0979-0 |
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