Effective sensitization of temozolomide by ABT-888 is lost with development of TMZ resistance in glioblastoma xenograft lines

Resistance to temozolomide (TMZ) and radiotherapy (RT) is a major problem for patients with GBM but may be overcome using the PARP-inhibitor ABT-888. Using two primary GBM xenografts, the efficacy of ABT-888 combined with RT and/or TMZ was evaluated. Treatment with ABT-888 combined with TMZ resulted...

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Autori principali: Clarke, Michelle J., Mulligan, Evan A., Grogan, Patrick T., Mladek, Ann C., Carlson, Brett L., Schroeder, Mark A., Curtin, Nicola J., Lou, Zhenkun, Decker, Paul A., Wu, Wenting, Plummer, E. Ruth, Sarkaria, Jann N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692390/
https://ncbi.nlm.nih.gov/pubmed/19174557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0854
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