Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

Temozolomide (TMZ)-based therapy is the standard of care for patients with glioblastoma multiforme (GBM), and resistance to this drug in GBM is modulated by the DNA repair protein O(6)-methylguanine-DNA methyl-transferase (MGMT). Expression of MGMT is silenced by promoter methylation in approximatel...

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Bibliographic Details
Main Authors: Kitange, Gaspar J., Carlson, Brett L., Schroeder, Mark A., Grogan, Patrick T., Lamont, Jeff D., Decker, Paul A., Wu, Wenting, James, C. David, Sarkaria, Jann N.
Format: Artigo
Language:Inglês
Published: Duke University Press 2009
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718972/
https://ncbi.nlm.nih.gov/pubmed/18952979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-090
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