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Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts
Temozolomide (TMZ)-based therapy is the standard of care for patients with glioblastoma multiforme (GBM), and resistance to this drug in GBM is modulated by the DNA repair protein O(6)-methylguanine-DNA methyl-transferase (MGMT). Expression of MGMT is silenced by promoter methylation in approximatel...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Duke University Press
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718972/ https://ncbi.nlm.nih.gov/pubmed/18952979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-090 |
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