Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models

BACKGROUND: Temozolomide (TMZ) is important chemotherapy for glioblastoma multiforme (GBM), but the optimal dosing schedule is unclear. METHODS: The efficacies of different clinically relevant dosing regimens were compared in a panel of 7 primary GBM xenografts in an intracranial therapy evaluation...

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Main Authors: Cen, Ling, Carlson, Brett L., Pokorny, Jenny L., Mladek, Ann C., Grogan, Patrick T., Schroeder, Mark A., Decker, Paul A., Anderson, S. Keith, Giannini, Caterina, Wu, Wenting, Ballman, Karla V., Kitange, Gaspar J., Sarkaria, Jann N.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661094/
https://ncbi.nlm.nih.gov/pubmed/23479134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not010
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