Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models

BACKGROUND: Temozolomide (TMZ) is important chemotherapy for glioblastoma multiforme (GBM), but the optimal dosing schedule is unclear. METHODS: The efficacies of different clinically relevant dosing regimens were compared in a panel of 7 primary GBM xenografts in an intracranial therapy evaluation...

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Main Authors: Cen, Ling, Carlson, Brett L., Pokorny, Jenny L., Mladek, Ann C., Grogan, Patrick T., Schroeder, Mark A., Decker, Paul A., Anderson, S. Keith, Giannini, Caterina, Wu, Wenting, Ballman, Karla V., Kitange, Gaspar J., Sarkaria, Jann N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2013
Ábhair:
Basic and Translational Investigations
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661094/
https://ncbi.nlm.nih.gov/pubmed/23479134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not010
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