ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

BACKGROUND: Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistance. Here, we tested whether inhibition of poly (AD...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Yuan, Alice L., Ricks, Christian B., Bohm, Alexandra K., Lun, Xueqing, Maxwell, Lori, Safdar, Shahana, Bukhari, Shazreh, Gerber, Amanda, Sayeed, Wajid, Bering, Elizabeth. A., Pedersen, Haley, Chan, Jennifer A., Shen, Yaoqing, Marra, Marco, Kaplan, David R., Mason, Warren, Goodman, Lindsey D., Ezhilarasan, Ravesanker, Kaufmann, Ascher B., Cabral, Matthew, Robbins, Steve M., Senger, Donna L., Cahill, Daniel P., Sulman, Erik P., Cairncross, J. Gregory, Blough, Michael D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112648/
https://ncbi.nlm.nih.gov/pubmed/30153289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202860
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