Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of 2 key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption of RBBP4 enhanced TMZ sensitivity, induced syntheti...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Kitange, Gaspar J., Mladek, Ann C., Schroeder, Mark A., Pokorny, Jenny C., Carlson, Brett L., Zhang, Yuji, Nair, Asha A., Lee, Jeong-Heon, Yan, Huihuang, Decker, Paul A., Zhang, Zhiguo, Sarkaria, Jann N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805508/
https://ncbi.nlm.nih.gov/pubmed/26972001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.045
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