Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins

Here we provide evidence that RBBP4 modulates temozolomide (TMZ) sensitivity through coordinate regulation of 2 key DNA repair genes critical for recovery from TMZ-induced DNA damage: methylguanine-DNA-methyltransferase (MGMT) and RAD51. Disruption of RBBP4 enhanced TMZ sensitivity, induced syntheti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Kitange, Gaspar J., Mladek, Ann C., Schroeder, Mark A., Pokorny, Jenny C., Carlson, Brett L., Zhang, Yuji, Nair, Asha A., Lee, Jeong-Heon, Yan, Huihuang, Decker, Paul A., Zhang, Zhiguo, Sarkaria, Jann N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805508/
https://ncbi.nlm.nih.gov/pubmed/26972001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.045
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg