Discordant in vitro and in vivo chemo-potentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

PURPOSE: Effective sensitizing strategies potentially can extend the benefit of TMZ therapy in GBM patients. We previously demonstrated that robust TMZ-sensitizing effects of the PARP inhibitor veliparib (ABT-888) are restricted to TMZ-sensitive GBM xenografts. The focus of this study is to provide...

Full description

Saved in:
Bibliographic Details
Main Authors: Gupta, Shiv K., Mladek, Ann C., Carlson, Brett L., Boakye-Agyeman, Felix, Bakken, Katrina, Kizilbash, Sani, Schroeder, Mark A., Reid, Joel, Sarkaria, Jann N.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111895/
https://ncbi.nlm.nih.gov/pubmed/24838527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3446
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items