Discordant in vitro and in vivo chemo-potentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts

PURPOSE: Effective sensitizing strategies potentially can extend the benefit of TMZ therapy in GBM patients. We previously demonstrated that robust TMZ-sensitizing effects of the PARP inhibitor veliparib (ABT-888) are restricted to TMZ-sensitive GBM xenografts. The focus of this study is to provide...

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Hlavní autoři: Gupta, Shiv K., Mladek, Ann C., Carlson, Brett L., Boakye-Agyeman, Felix, Bakken, Katrina, Kizilbash, Sani, Schroeder, Mark A., Reid, Joel, Sarkaria, Jann N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111895/
https://ncbi.nlm.nih.gov/pubmed/24838527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3446
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