PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity

Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM cells to chemo-radiation is expected to extend surv...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Gupta, Shiv K., Smith, Emily J., Mladek, Ann C., Tian, Shulan, Decker, Paul A., Kizilbash, Sani H., Kitange, Gaspar J., Sarkaria, Jann N.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349736/
https://ncbi.nlm.nih.gov/pubmed/30723695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00670
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