DDIS-01. THE ANTIBODY-DRUG CONJUGATE ABT-414 DEMONSTRATES SINGLE-AGENT ANTI-CANCER ACTIVITY ACROSS A PANEL OF GBM PATIENT-DERIVED XENOGRAFTS

ABT-414 is a novel antibody-drug conjugate (ADC) of monomethyl auristatin F (MMAF), a microtubule destabilizing agent, and an anti-EGFR antibody (ABT-806). ABT-414 has demonstrated promising efficacy in clinical trials against newly diagnosed and recurrent glioblastoma (GBM), but little is known abo...

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Publicado no:Neuro Oncol
Main Authors: Marin, Bianca, Mladek, Ann, Burgenske, Danielle, He, Lihong, Hu, Zeng, Bakken, Katrina, Carlson, Brett, Schroeder, Mark, Sarkaria, Jann
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217207/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.280
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