Novel Ricin Subunit Antigens with Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice

RiVax is a candidate ricin toxin subunit vaccine antigen that has proven to be safe in human Phase I clinical trials. In this study we introduced double and triple cavity-filling point mutations into the RiVax antigen with the expectation that stability enhancing modifications would have a beneficia...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Wahome, Newton, Sully, Erin, Singer, Christopher, Thomas, Justin C., Hu, Lei, Joshi, Sangeeta B., Volkin, David B., Fang, Jianwen, Karanicolas, John, Jacobs, Donald J., Mantis, Nicholas J., Middaugh, C. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846473/
https://ncbi.nlm.nih.gov/pubmed/26987947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.02.009
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