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Structural Analysis of Nested Neutralizing and Non-Neutralizing B cell Epitopes on Ricin Toxin's Enzymatic Subunit

In this report we describe the X-ray crystal structures of two single domain camelid antibodies (V(H)H), F5 and F8, each in complex with the ricin toxin's enzymatic subunit (RTA). F5 has potent toxin-neutralizing activity, while F8 has weak neutralizing activity. F5 buried a total of 1760 Å(2)...

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Bibliografische gegevens
Gepubliceerd in:Proteins
Hoofdauteurs: Rudolph, Michael J., Vance, David J., Cassidy, Michael S., Rong, Yinghui, Shoemaker, Charles B., Mantis, Nicholas J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945499/
https://ncbi.nlm.nih.gov/pubmed/27159829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25062
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