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Structural Analysis of Nested Neutralizing and Non-Neutralizing B cell Epitopes on Ricin Toxin's Enzymatic Subunit
In this report we describe the X-ray crystal structures of two single domain camelid antibodies (V(H)H), F5 and F8, each in complex with the ricin toxin's enzymatic subunit (RTA). F5 has potent toxin-neutralizing activity, while F8 has weak neutralizing activity. F5 buried a total of 1760 Å(2)...
Kaydedildi:
| Yayımlandı: | Proteins |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945499/ https://ncbi.nlm.nih.gov/pubmed/27159829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25062 |
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