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Export of Precursor tRNA(Ile) from the Nucleus to the Cytoplasm in Human Cells

In the current concept, tRNA maturation in vertebrate cells, including splicing of introns, trimming of 5’ leader and 3’ trailer, and adding of CCA, is thought to occur exclusively in the nucleus. Here we provide evidence to challenge this concept. Unspliced intron-containing precursor tRNA(Ile) was...

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Pubblicato in:PLoS One
Autori principali: Wei, Min, Zhao, Xia, Liu, Mi, Niu, Meijuan, Seif, Elias, Kleiman, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839721/
https://ncbi.nlm.nih.gov/pubmed/27101286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154044
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