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Export of Precursor tRNA(Ile) from the Nucleus to the Cytoplasm in Human Cells

In the current concept, tRNA maturation in vertebrate cells, including splicing of introns, trimming of 5’ leader and 3’ trailer, and adding of CCA, is thought to occur exclusively in the nucleus. Here we provide evidence to challenge this concept. Unspliced intron-containing precursor tRNA(Ile) was...

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Publicat a:PLoS One
Autors principals: Wei, Min, Zhao, Xia, Liu, Mi, Niu, Meijuan, Seif, Elias, Kleiman, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839721/
https://ncbi.nlm.nih.gov/pubmed/27101286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154044
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