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Targeting mTOR and p53 signaling inhibits muscle invasive bladder cancer in vivo

Urothelial tumors, accompanied by mutations of the tumor suppressor protein TP53 and dysregulation of mTOR signaling, are frequently associated with aggressive growth and invasiveness. We investigated whether targeting these two pathways would inhibit urothelial tumor growth and progression. Six-wee...

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Bibliografski detalji
Izdano u:Cancer Prev Res (Phila)
Glavni autori: Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Biddick, Laura, Patlolla, Jagan M.R., Lightfoot, Stan, Towner, Rheal A., Wu, Xue-Ru, Steele, Vernon E., Kopelovich, Levy, Rao, Chinthalapally V.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839263/
https://ncbi.nlm.nih.gov/pubmed/26577454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0199
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