Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice

In tobacco-associated lung cancers, the protein kinase B/mammalian target of rapamycin (Akt/mTOR) pathway frequently is activated by nicotine and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The aim of the present study was to examine the effects of early or late intervention...

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Publicado no:Oncol Rep
Main Authors: PATLOLLA, JAGAN M.R., KOPELOVICH, LEVY, QIAN, LI, ZHANG, YUTING, KUMAR, GAURAV, MADKA, VENKATESHWAR, MOHAMMED, ALTAF, BIDDICK, LAURA, SADEGHI, MICHAEL, LIGHTFOOT, STAN, RAO, CHINTHALAPALLY V.
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735698/
https://ncbi.nlm.nih.gov/pubmed/26397133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4277
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