Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice

Lung cancer is the leading cause of cancer deaths worldwide. Targeting complementary pathways will achieve better treatment efficacy than a single agent high-dose strategy that could increase risk of side effects and tumor resistance. To target COX-2, 5-LOX, and ODC simultaneously, we tested the eff...

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Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Kumar, Gaurav, Patlolla, Jagan Mohan R, Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Biddick, Laura, Singh, Anil, Gillaspy, Allison, Lightfoot, Stanley, Steele, Vernon E, Kopelovich, Levy, Rao, Chinthalapally V
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889708/
https://ncbi.nlm.nih.gov/pubmed/27293987
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