TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma

Mutations of the tumor suppressor p53 and elevated levels of polyamines are known to play key roles in urothelial tumorigenesis. We investigated the inhibition of polyamines biosynthesis and the restoration of p53 signaling as a possible means of preventing muscle invasive urothelial tumors using DF...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Cancer Res
Prif Awduron: Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Kumar, Gaurav, Lightfoot, Stan, Wu, Xueru, Steele, Vernon, Kopelovich, Levy, Rao, Chinthalapally V
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: e-Century Publishing Corporation 2015
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656728/
https://ncbi.nlm.nih.gov/pubmed/26693057
Tagiau: Ychwanegu Tag
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