TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma

Mutations of the tumor suppressor p53 and elevated levels of polyamines are known to play key roles in urothelial tumorigenesis. We investigated the inhibition of polyamines biosynthesis and the restoration of p53 signaling as a possible means of preventing muscle invasive urothelial tumors using DF...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Kumar, Gaurav, Lightfoot, Stan, Wu, Xueru, Steele, Vernon, Kopelovich, Levy, Rao, Chinthalapally V
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656728/
https://ncbi.nlm.nih.gov/pubmed/26693057
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