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Inhibition of AOM-Induced Colorectal Cancer by CP-31398, a TP53 modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats
Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53 modulating agent CP-31398 alone and combined with celecoxib on azoxymethane (AOM)-induced aberrant crypt foci (ACF) and colon adenocarcinomas in F344 rats. Maximum tolerated doses...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2792897/ https://ncbi.nlm.nih.gov/pubmed/19826045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1377 |
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