Inhibition of AOM-Induced Colorectal Cancer by CP-31398, a TP53 modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats

Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53 modulating agent CP-31398 alone and combined with celecoxib on azoxymethane (AOM)-induced aberrant crypt foci (ACF) and colon adenocarcinomas in F344 rats. Maximum tolerated doses...

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Hlavní autoři: Rao, Chinthalapally V., Steele, Vernon E., Swamy, Malisetty V., Patlolla, Jagan M.R., Guruswamy, Suresh, Kopelovich, Levy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792897/
https://ncbi.nlm.nih.gov/pubmed/19826045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1377
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