Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats

Nitric oxide-donating aspirin (NO-ASA) represents class of promising chemopreventive NO-NSAIDs. NO-ASA combines the beneficial effects of ASA and the gut-sparing effect of the NO moiety. There is, however, limited information on its pharmacokinetic and pharmacodynamic effects in vivo. Herein, experi...

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Hlavní autoři: RAO, CHINTHALAPALLY V., JOSEPH, STANCY, GAO, LI, PATLOLLA, JAGAN M.R., CHOI, CHANG-IN, KOPELOVICH, LEVY, STEELE, VERNON E., RIGAS, BASIL
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579329/
https://ncbi.nlm.nih.gov/pubmed/18813794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo_00000067
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