Targeting mTOR and p53 signaling inhibits muscle invasive bladder cancer in vivo

Urothelial tumors, accompanied by mutations of the tumor suppressor protein TP53 and dysregulation of mTOR signaling, are frequently associated with aggressive growth and invasiveness. We investigated whether targeting these two pathways would inhibit urothelial tumor growth and progression. Six-wee...

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Gepubliceerd in:Cancer Prev Res (Phila)
Hoofdauteurs: Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Biddick, Laura, Patlolla, Jagan M.R., Lightfoot, Stan, Towner, Rheal A., Wu, Xue-Ru, Steele, Vernon E., Kopelovich, Levy, Rao, Chinthalapally V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839263/
https://ncbi.nlm.nih.gov/pubmed/26577454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0199
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