Adenosine A(1) Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea. Recent studies implicate ROS generation in mediating inflammatory and apoptotic processes and...

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Pubblicato in:J Neurosci
Autori principali: Kaur, Tejbeer, Borse, Vikrant, Sheth, Sandeep, Sheehan, Kelly, Ghosh, Sumana, Tupal, Srinivasan, Jajoo, Sarvesh, Mukherjea, Debashree, Rybak, Leonard P., Ramkumar, Vickram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821909/
https://ncbi.nlm.nih.gov/pubmed/27053204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3111-15.2016
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