Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea

Capsaicin, the spicy component of hot chili peppers activates the TRPV1 pain receptors, and causes rapid desensitization. Capsaicin also ameliorates cisplatin-induced nephrotoxicity. Cisplatin, a commonly used anti-neoplastic agent for solid tumors causes significant hearing loss, nephrotoxicity and...

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Publicado en:Sci Rep
Autores principales: Bhatta, Puspanjali, Dhukhwa, Asmita, Sheehan, Kelly, Al Aameri, Raheem F.H, Borse, Vikrant, Ghosh, Sumana, Sheth, Sandeep, Mamillapalli, Chaitanya, Rybak, Leonard, Ramkumar, Vickram, Mukherjea, Debashree
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411993/
https://ncbi.nlm.nih.gov/pubmed/30858408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40425-9
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