Adenosine A(1) Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea. Recent studies implicate ROS generation in mediating inflammatory and apoptotic processes and...

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Publicado no:J Neurosci
Main Authors: Kaur, Tejbeer, Borse, Vikrant, Sheth, Sandeep, Sheehan, Kelly, Ghosh, Sumana, Tupal, Srinivasan, Jajoo, Sarvesh, Mukherjea, Debashree, Rybak, Leonard P., Ramkumar, Vickram
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821909/
https://ncbi.nlm.nih.gov/pubmed/27053204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3111-15.2016
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