Adenosine A(1) Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea. Recent studies implicate ROS generation in mediating inflammatory and apoptotic processes and...

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Опубликовано в: :J Neurosci
Главные авторы: Kaur, Tejbeer, Borse, Vikrant, Sheth, Sandeep, Sheehan, Kelly, Ghosh, Sumana, Tupal, Srinivasan, Jajoo, Sarvesh, Mukherjea, Debashree, Rybak, Leonard P., Ramkumar, Vickram
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821909/
https://ncbi.nlm.nih.gov/pubmed/27053204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3111-15.2016
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