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Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity

Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea. At the cellular level, cisplatin increases reactive oxygen species (ROS) leading to cochlear inflammation and apopto...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Borse, Vikrant, Al Aameri, Raheem F H, Sheehan, Kelly, Sheth, Sandeep, Kaur, Tejbeer, Mukherjea, Debashree, Tupal, Srinivasan, Lowy, Michelle, Ghosh, Sumana, Dhukhwa, Asmita, Bhatta, Puspanjali, Rybak, Leonard P, Ramkumar, Vickram
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550861/
https://ncbi.nlm.nih.gov/pubmed/28703809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.314
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