Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat

Cisplatin produces hearing loss in cancer patients. Reactive oxygen species (ROS) in the cochlea leads to lipid peroxidation, death of outer hair cells (OHCs), and hearing loss. The cochlea expresses a unique isoform of NADPH oxidase, NOX3, which serves as the primary source of ROS generation in the...

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Hlavní autoři: Mukherjea, Debashree, Jajoo, Sarvesh, Kaur, Tejbeer, Sheehan, Kelly E., Ramkumar, Vickram, Rybak, Leonard P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2010
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935347/
https://ncbi.nlm.nih.gov/pubmed/20214492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3110
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