Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea

Capsaicin, the spicy component of hot chili peppers activates the TRPV1 pain receptors, and causes rapid desensitization. Capsaicin also ameliorates cisplatin-induced nephrotoxicity. Cisplatin, a commonly used anti-neoplastic agent for solid tumors causes significant hearing loss, nephrotoxicity and...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Bhatta, Puspanjali, Dhukhwa, Asmita, Sheehan, Kelly, Al Aameri, Raheem F.H, Borse, Vikrant, Ghosh, Sumana, Sheth, Sandeep, Mamillapalli, Chaitanya, Rybak, Leonard, Ramkumar, Vickram, Mukherjea, Debashree
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411993/
https://ncbi.nlm.nih.gov/pubmed/30858408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40425-9
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