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Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse

Monocyte-derived cells use an extracellular, acidic, lytic compartment (a lysosomal synapse) for initial degradation of large objects or species bound to the extracellular matrix. Akin to osteoclast degradation of bone, extracellular catabolism is used by macrophages to degrade aggregates of low den...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Singh, Rajesh K., Barbosa-Lorenzi, Valéria C., Lund, Frederik W., Grosheva, Inna, Maxfield, Frederick R., Haka, Abigail S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813320/
https://ncbi.nlm.nih.gov/pubmed/26801085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.181743
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