Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and ceramide. Increased ceramide levels are prese...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Main Authors: Singh, Rajesh K., Haka, Abigail S., Brumfield, Alexandria, Grosheva, Inna, Bhardwaj, Priya, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625121/
https://ncbi.nlm.nih.gov/pubmed/28814641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076398
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