Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and ceramide. Increased ceramide levels are prese...

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Bibliographische Detailangaben
Veröffentlicht in:J Lipid Res
Hauptverfasser: Singh, Rajesh K., Haka, Abigail S., Brumfield, Alexandria, Grosheva, Inna, Bhardwaj, Priya, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625121/
https://ncbi.nlm.nih.gov/pubmed/28814641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076398
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