Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and ceramide. Increased ceramide levels are prese...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Singh, Rajesh K., Haka, Abigail S., Brumfield, Alexandria, Grosheva, Inna, Bhardwaj, Priya, Chin, Harvey F., Xiong, Yuquan, Hla, Timothy, Maxfield, Frederick R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625121/
https://ncbi.nlm.nih.gov/pubmed/28814641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076398
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