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Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization

OBJECTIVE: Interaction of macrophages with aggregated matrix-anchored lipoprotein deposits is an important initial step in atherogenesis. Aggregated lipoproteins require different cellular uptake processes than those used for endocytosis of monomeric lipoproteins. In this study, we tested the hypoth...

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Détails bibliographiques
Auteurs principaux: Grosheva, Inna, Haka, Abigail S., Qin, Chunbo, Pierini, Lynda M., Maxfield, Frederick R.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755184/
https://ncbi.nlm.nih.gov/pubmed/19556523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.191882
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