Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in t...

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Опубликовано в: :Acta Neuropathol
Главные авторы: Kumar, Sathish, Wirths, Oliver, Stüber, Kathrin, Wunderlich, Patrick, Koch, Philipp, Theil, Sandra, Rezaei-Ghaleh, Nasrollah, Zweckstetter, Markus, Bayer, Thomas A., Brüstle, Oliver, Thal, Dietmar R., Walter, Jochen
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2016
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789232/
https://ncbi.nlm.nih.gov/pubmed/26898910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1546-0
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