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Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation
Assembly of β-amyloid (Aβ) peptide into toxic oligomers is widely believed to initiate Alzheimer's disease pathogenesis. Under in vitro physiological conditions, zinc (Zn(II)) can bind to Aβ and redirect its assembly from amyloid fibrillar toward less toxic amorphous aggregation. Propensity of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164126/ https://ncbi.nlm.nih.gov/pubmed/21889458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.062 |
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