Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation

Assembly of β-amyloid (Aβ) peptide into toxic oligomers is widely believed to initiate Alzheimer's disease pathogenesis. Under in vitro physiological conditions, zinc (Zn(II)) can bind to Aβ and redirect its assembly from amyloid fibrillar toward less toxic amorphous aggregation. Propensity of...

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Autores principales: Rezaei-Ghaleh, Nasrollah, Giller, Karin, Becker, Stefan, Zweckstetter, Markus
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2011
Materias:
Protein
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164126/
https://ncbi.nlm.nih.gov/pubmed/21889458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.062
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