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Phosphorylation modifies the molecular stability of β-amyloid deposits

Protein aggregation plays a crucial role in neurodegenerative diseases. A key feature of protein aggregates is their ubiquitous modification by phosphorylation. Little is known, however, about the molecular consequences of phosphorylation of protein aggregates. Here we show that phosphorylation of β...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Rezaei-Ghaleh, Nasrollah, Amininasab, Mehriar, Kumar, Sathish, Walter, Jochen, Zweckstetter, Markus
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833870/
https://ncbi.nlm.nih.gov/pubmed/27072999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11359
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