Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

Aggregation and toxicity of the amyloid β-peptide (Aβ) are considered as critical events in the initiation and progression of Alzheimer’s disease (AD). Recent evidence indicated that soluble oligomeric Aβ assemblies exert pronounced toxicity, rather than larger fibrillar aggregates that deposit in t...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Kumar, Sathish, Wirths, Oliver, Stüber, Kathrin, Wunderlich, Patrick, Koch, Philipp, Theil, Sandra, Rezaei-Ghaleh, Nasrollah, Zweckstetter, Markus, Bayer, Thomas A., Brüstle, Oliver, Thal, Dietmar R., Walter, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789232/
https://ncbi.nlm.nih.gov/pubmed/26898910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1546-0
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