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Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the efflux of a variety of hydrophobic and amphipathic compounds including anticancer drugs. Most of the substrates and modulators of P-gp stimula...

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Bibliografische gegevens
Gepubliceerd in:Biochem Pharmacol
Hoofdauteurs: Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753104/
https://ncbi.nlm.nih.gov/pubmed/26686578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.12.007
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