Inhibition of Multidrug Resistance-Linked P-Glycoprotein (ABCB1) Function by 5′-Fluorosulfonylbenzoyl 5′-Adenosine: Evidence for an ATP Analog That Interacts With Both Drug-Substrate- and Nucleotide-Binding Sites

5′-fluorosulfonylbenzonyl 5′-adenosine (FSBA) is an ATP analog that covalently modifies several residues in the nucleotide-binding domains (NBDs) of several ATPases, kinases and other proteins. P-glycoprotein (P-gp, ABCB1) is a member of the ATP-binding cassette (ABC) transporter superfamily that ut...

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Main Authors: Ohnuma, Shinobu, Chufan, Eduardo, Nandigama, Krishnamachary, Miller Jenkins, Lisa M., Durell, Stewart R., Appella, Ettore, Sauna, Zuben E., Ambudkar, Suresh V.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108491/
https://ncbi.nlm.nih.gov/pubmed/21452853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200073f
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