Llwytho...

Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the efflux of a variety of hydrophobic and amphipathic compounds including anticancer drugs. Most of the substrates and modulators of P-gp stimula...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753104/
https://ncbi.nlm.nih.gov/pubmed/26686578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.12.007
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!