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Dissecting Structure-Activity-Relationships of Crebinostat: Brain Penetrant HDAC Inhibitors for Neuroepigenetic Regulation
Targeting chromatin-mediated epigenetic regulation has emerged as a potential avenue for developing novel therapeutics for a wide range of central nervous system disorders, including cognitive disorders and depression. Histone deacetylase (HDAC) inhibitors have been pursued as cognitive enhancers th...
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| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753070/ https://ncbi.nlm.nih.gov/pubmed/26804233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.022 |
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